Recent Publications
Ulu A and Frost J.A. (2016) Regulation of RhoA activation and cytoskeletal organization by acetylation. 7(2):76-81. (PDF)
Zuo Y, Oh W, Ulu A, Frost JA. (2016) Mouse Models of Rho GTPase function in mammary gland development. Mol. Endo., 30(3):278-89. (PDF)
Song, E.H., Carr, H.S., Zuo, Y. and Frost, J.A. (2015) Acetylation dependent regulation of the subcellular localization and activity of the RhoGEF Net1A. J. Cell. Sci., 128(5):913-22. (PDF)
Zuo, Y., Berdeaux, R. and Frost, J.A. (2014) The RhoGEF Net1 is required for normal mammary gland development. Mol. Endo., 28(12):1948-60. (PDF)
Zuo, Y., Oh, W. and Frost, J.A. (2014) Controlling the switches: Rho GTPase regulation during animal cell mitosis. Cell. Signalling, 26(12):2998-3006. (PDF)
Oh, W. and Frost, J.A. (2014) Rho GTPase independent regulation of ATM activation and cell survival by the RhoGEF Net1A. Cell cycle, 13(17):2765-72. (Pubmed)
Yang, Q., Wu, Z., Hadden, J.K., Crook, R.J., Zuo, Y., Frost, J.A. and Walters, E.T. (2014) Persistent pain after spinal cord injury is maintained by primary afferent activity, J. Neurosci., 34(32):10765-9. (PDF)
Menon, S. and Frost, J.A. (2013) The RhoA GEF Net1 controls mitotic Pak and Aurora A activation to regulate mitotic progression. Mol. Biol. Cell., 24(17), 2655-2657. (PDF)
Carr, H.S. and Frost, J.A. (2013) Timing is everything: Rac1 controls Net1A localization to regulate cell adhesion. Cell Adhes. Migrat., 7(4), 351-356. (PDF)
Carr H.S., Zuo, Y., Oh, W. and Frost, J.A. (2013) The RhoA GEF Net1 controls FAK activation to regulate breast cancer cell migration and invasion. Mol. Cell. Biol. 33(14), 2773-2786. (PDF)
Carr, H.S., Morris, C.A., Menon, S., Song, E.H., Frost, J.A. (2013) Rac1 controls the subcellular localization of the RhoGEF Net1A to regulated focal adhesion formation and cell spreading. Mol. Cell. Biol., 33(3), 622-634. (PDF)
Frost, J.A. (2011) Net1. Encyclopedia of Signaling Molecules.
Pichot, C.S., Hartig, S.M., Arvanitis, D., Jensen, S., Bechill, J., Marzouk, S., Scita, G., Frost, J.A., Corey, S.J. (2010) Cdc42 Interacting Protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp, Cancer Res., 70, 8347-8356. (PDF)
Ross, J.A., Hanyin Cheng, H., Nagy, Z.S., Frost, J.A., and Kirken, R.A. (2010) Protein Phosphatase 2A (PP2A) regulates Interleukin-2 Receptor complex formation and JAK3/STAT5 activation, J. Biol. Chem., 285, 3582-3591. (PDF)
Carr, H.S., Cai, C., Keinanen, K., and Frost, J.A. (2009) Interaction of the RhoA exchange factor Net1 with Dlg1 protects it from proteasome mediated degradation and potentiates Net1 activity, J. Biol. Chem., 284, 24269-24280. (PDF)
Pichot, C.S., Hartig, M., Xia, L., Lee, F.Y., Frost, J.A., and Corey, S.J. (2009) Dasatinib Synergizes with Doxorubicin to Block Growth, Migration, and Invasion of Breast Cancer Cells, Brit. J. Cancer, 101(1), 38-47. (PDF)
Gilcrease, M.Z., Kilpatrick, S.K., Woodward, W.A., Zhou, X., Nicolas, M.M., Corley, L.J., Fuller, G.N., Tucker, S.L., Diaz, L.K., Buchholz, T.A., and Frost, J.A. (2009) Co-Expression of Beta4 Integrin and Guanine Nucleotide Exchange Factor Net1 Identifies an Aggressive Subgroup of HER2-Positive Breast Cancer. Cancer Epidemiology, Biomarkers and Prevention, 18, 80-86. (PDF)
Wu, X., Carr, H.S., Dan, I., Ruvolo, P.P, and Frost, J.A. (2008) p21 activated kinase 5 activates Raf-1 and targets it to mitochondria. J. Cell. Biochem. 105, 167-175. (PDF)
Guerra, L., Carr, H., Richter-Dahlfors, A., Thelestam, M., Masucci, M.G., Frost, J.A., and Frisan, T. (2008) A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a key effector in the response to DNA damage. PLoS ONE, 3(5), e2254. (PDF)
Cheng, H., Ross J.A., Frost, J.A., and Kirken, R.A. (2008) Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity. Mol. Cell. Biol. 28(7), 2271-2282. (PDF)
Frost, J.A. (2008) Net1. UCSD-Nature Molecule Pages (doi:10.1038/mp.a001630.01).
Garcia-Mata, R., Dubash, A., Sharek, L., Carr, H.S., Frost, J.A., and Burridge, K. (2007) The nuclear RhoA exchange factor NET1 interacts with proteins of the DLG family, affects their localization and influences their tumor suppressive activity. Mol. Cell. Biol. 27(24), 8683-8697. (PDF)
Zuo Y, Oh W, Ulu A, Frost JA. (2016) Mouse Models of Rho GTPase function in mammary gland development. Mol. Endo., 30(3):278-89. (PDF)
Song, E.H., Carr, H.S., Zuo, Y. and Frost, J.A. (2015) Acetylation dependent regulation of the subcellular localization and activity of the RhoGEF Net1A. J. Cell. Sci., 128(5):913-22. (PDF)
Zuo, Y., Berdeaux, R. and Frost, J.A. (2014) The RhoGEF Net1 is required for normal mammary gland development. Mol. Endo., 28(12):1948-60. (PDF)
Zuo, Y., Oh, W. and Frost, J.A. (2014) Controlling the switches: Rho GTPase regulation during animal cell mitosis. Cell. Signalling, 26(12):2998-3006. (PDF)
Oh, W. and Frost, J.A. (2014) Rho GTPase independent regulation of ATM activation and cell survival by the RhoGEF Net1A. Cell cycle, 13(17):2765-72. (Pubmed)
Yang, Q., Wu, Z., Hadden, J.K., Crook, R.J., Zuo, Y., Frost, J.A. and Walters, E.T. (2014) Persistent pain after spinal cord injury is maintained by primary afferent activity, J. Neurosci., 34(32):10765-9. (PDF)
Menon, S. and Frost, J.A. (2013) The RhoA GEF Net1 controls mitotic Pak and Aurora A activation to regulate mitotic progression. Mol. Biol. Cell., 24(17), 2655-2657. (PDF)
Carr, H.S. and Frost, J.A. (2013) Timing is everything: Rac1 controls Net1A localization to regulate cell adhesion. Cell Adhes. Migrat., 7(4), 351-356. (PDF)
Carr H.S., Zuo, Y., Oh, W. and Frost, J.A. (2013) The RhoA GEF Net1 controls FAK activation to regulate breast cancer cell migration and invasion. Mol. Cell. Biol. 33(14), 2773-2786. (PDF)
Carr, H.S., Morris, C.A., Menon, S., Song, E.H., Frost, J.A. (2013) Rac1 controls the subcellular localization of the RhoGEF Net1A to regulated focal adhesion formation and cell spreading. Mol. Cell. Biol., 33(3), 622-634. (PDF)
Frost, J.A. (2011) Net1. Encyclopedia of Signaling Molecules.
Pichot, C.S., Hartig, S.M., Arvanitis, D., Jensen, S., Bechill, J., Marzouk, S., Scita, G., Frost, J.A., Corey, S.J. (2010) Cdc42 Interacting Protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp, Cancer Res., 70, 8347-8356. (PDF)
Ross, J.A., Hanyin Cheng, H., Nagy, Z.S., Frost, J.A., and Kirken, R.A. (2010) Protein Phosphatase 2A (PP2A) regulates Interleukin-2 Receptor complex formation and JAK3/STAT5 activation, J. Biol. Chem., 285, 3582-3591. (PDF)
Carr, H.S., Cai, C., Keinanen, K., and Frost, J.A. (2009) Interaction of the RhoA exchange factor Net1 with Dlg1 protects it from proteasome mediated degradation and potentiates Net1 activity, J. Biol. Chem., 284, 24269-24280. (PDF)
Pichot, C.S., Hartig, M., Xia, L., Lee, F.Y., Frost, J.A., and Corey, S.J. (2009) Dasatinib Synergizes with Doxorubicin to Block Growth, Migration, and Invasion of Breast Cancer Cells, Brit. J. Cancer, 101(1), 38-47. (PDF)
Gilcrease, M.Z., Kilpatrick, S.K., Woodward, W.A., Zhou, X., Nicolas, M.M., Corley, L.J., Fuller, G.N., Tucker, S.L., Diaz, L.K., Buchholz, T.A., and Frost, J.A. (2009) Co-Expression of Beta4 Integrin and Guanine Nucleotide Exchange Factor Net1 Identifies an Aggressive Subgroup of HER2-Positive Breast Cancer. Cancer Epidemiology, Biomarkers and Prevention, 18, 80-86. (PDF)
Wu, X., Carr, H.S., Dan, I., Ruvolo, P.P, and Frost, J.A. (2008) p21 activated kinase 5 activates Raf-1 and targets it to mitochondria. J. Cell. Biochem. 105, 167-175. (PDF)
Guerra, L., Carr, H., Richter-Dahlfors, A., Thelestam, M., Masucci, M.G., Frost, J.A., and Frisan, T. (2008) A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a key effector in the response to DNA damage. PLoS ONE, 3(5), e2254. (PDF)
Cheng, H., Ross J.A., Frost, J.A., and Kirken, R.A. (2008) Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity. Mol. Cell. Biol. 28(7), 2271-2282. (PDF)
Frost, J.A. (2008) Net1. UCSD-Nature Molecule Pages (doi:10.1038/mp.a001630.01).
Garcia-Mata, R., Dubash, A., Sharek, L., Carr, H.S., Frost, J.A., and Burridge, K. (2007) The nuclear RhoA exchange factor NET1 interacts with proteins of the DLG family, affects their localization and influences their tumor suppressive activity. Mol. Cell. Biol. 27(24), 8683-8697. (PDF)
